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1-(Trifluoromethyl)-3,4-dihydropyrrolo-[1,2-a] pyrazines: synthesis and reactions with O- and N-nucleophiles

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Chemistry of Heterocyclic Compounds Aims and scope

The method of synthesis has been developed and reactions of 1-(trifluoromethyl)-3,4-dihydro-pyrrolo[1,2-a]pyrazines with O- and N-nucleophiles have been studied. It was found that reactions of nucleophiles with 1-(trifluoro-methyl)pyrrolo[1,2-a]pyrazines transforms the trifluoromethyl group to amide and amidine groups together with aromatization of the pyrrolo[1,2-a]pyrazine system as a result of the formal elimination of a molecule of hydrogen fluoride.

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Authors and Affiliations

  1. M. V. Lomonosov State University, Moscow, 119992, Russia

    V. I. Terenin, M. V. Galkin, E. V. Kabanova & A. S. Ivanov

Authors
  1. V. I. Terenin
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  2. M. V. Galkin
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  3. E. V. Kabanova
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  4. A. S. Ivanov
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Correspondence to V. I. Terenin.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1569-1578, October, 2010.

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Terenin, V.I., Galkin, M.V., Kabanova, E.V. et al. 1-(Trifluoromethyl)-3,4-dihydropyrrolo-[1,2-a] pyrazines: synthesis and reactions with O- and N-nucleophiles. Chem Heterocycl Comp 46, 1271–1278 (2011). https://doi.org/10.1007/s10593-011-0663-x

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  • DOI: https://doi.org/10.1007/s10593-011-0663-x

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