Convenient preparative methods have been developed for the reduction of the active substance of the medicinal preparation Dimebon (2,8-dimethyl-5-[2-(6-methylpyrid-3-yl)ethyl]-1,2,3,4-tetrahydro-γ-carboline) to the corresponding racemic cis- and trans-1,2,3,4,4a,9b-hexahydro derivatives, distinguished by a high degree of stereoselectivity. The structures of the obtained diastereomeric hexahydro-γ-carbolines were confirmed by various physicochemical methods, including X-ray structural analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1533-1545, October, 2010.
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Alekseyev, R.S., Ivanov, A.S., Kurkin, A.V. et al. Stereoselective reduction of the active substance of the medicinal preparation dimeb n to the corresponding cis- and trans-1,2,3,4,4a,9b-hexahydro derivatives. Chem Heterocycl Comp 46, 1239–1249 (2011). https://doi.org/10.1007/s10593-011-0658-7
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DOI: https://doi.org/10.1007/s10593-011-0658-7