Chemistry of Heterocyclic Compounds

, Volume 46, Issue 9, pp 1127–1132 | Cite as

Condensed diazepines. synthesis of 1-aryl-3,5-dihydro-4H-1-benzofuro-[2,3-d][1,2]diazepin-4-ones

  • A. B. Eresko
  • V. S. Tolkunov
  • S. V. TolkunovEmail author

The cyclocondensation of (2-aroyl-1-benzofuran-3-yl)acetic acids and their methyl esters with hydrazine hydrate under various experimental conditions has been studied. Optimal conditions have been found for obtaining 1-aryl-3,5-dihydro-4H-1-benzofuro[2,3-d][1,2]diazepin-4-ones.


(2-aroyl-1-benzofuran-3-yl)-acetic acids 1-aryl-3,5-dihydro-4H-1-benzofuro[2,3-d][1,2]diazepin- 4-ones hydrazine hydrate condensed diazepines polyphosphoric acid benzoylation cyclization 


  1. 1.
    A. Sarro, G. Sarro, R. Gitto, S. Grasso, N. Micale, and M. Zappala, Farmaco, 54, 178 (1999).CrossRefGoogle Scholar
  2. 2.
    S. Quartarone, R. Caruso, V. Orlando, E. Russo, G. Sarro, and A. Chimirri, Farmaco, 59, 353 (2004).CrossRefGoogle Scholar
  3. 3.
    R. Gitto, M. Zappala, G. Sarro, and A. Chimirri, Farmaco, 57, 129 (2002).CrossRefGoogle Scholar
  4. 4.
    A. Chimirri, G. Sarro, A. Sarro, R. Gitto, S. Quartarone, M. Zappala, A. Constanti, and V. Libri, J. Med. Chem., 41, 3409 (1998).CrossRefGoogle Scholar
  5. 5.
    F. Bevacqua, A. Basso, R. Gitto, M. Bradley, and A. Chimirri, Tetrahedron Lett., 42, 7683 (2001).CrossRefGoogle Scholar
  6. 6.
    F. Gatta, D. Piazza, M. R. Del Giudice, and M. Massotti, Farmaco Ed. Sc., 40, 942 (1985).Google Scholar
  7. 7.
    A. Monge, M. T. Martinez, J. A. Palop, J. M. Mateo, and E. Fernandez-Alvarez, J. Heterocycl. Chem., 18, 889 (1981).CrossRefGoogle Scholar
  8. 8.
    A. Monge, M. T. Martinez, J. A. Palop, J. M. Mateo, T. Goni, E. Fernandez-Alvarez, J. Heterocycl. Chem., 21, 381 (1984)CrossRefGoogle Scholar
  9. 9.
    A. Monge, J. A. Palop, T. Goni, A. Martinez, and E. Fernandez-Alvarez, J. Heterocycl. Chem., 22, 1445 (1985).CrossRefGoogle Scholar
  10. 10.
    V. S. Tolkunov, I. F. Perepichka, and V. I. Dulenko, J. Heterocycl. Chem., 42, 811 (2005).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  • A. B. Eresko
    • 1
  • V. S. Tolkunov
    • 1
  • S. V. Tolkunov
    • 1
    Email author
  1. 1.L. M. Litvinenko Institute of Physical-Organic Chemistry and Coal ChemistryNational Academy of Sciences of UkraineDonetskUkraine

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