Chemistry of Heterocyclic Compounds

, Volume 46, Issue 9, pp 1105–1108 | Cite as

Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives

  • A. Sh. El-Etrawy
  • A. A.-H. Abdel-RahmanEmail author

Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.


pyrimidine derivatives 1,2,3-triazoles anti hepatitis A virus cycloaddition 


  1. 1.
    S. Patai (editor), The Chemistry of the Azido Group, Interscience, New York, 1971.Google Scholar
  2. 2.
    N. A. Ridois, J. Heterocycl. Chem., 21, 1169 (1984).CrossRefGoogle Scholar
  3. 3.
    E. F. V. Scriven and K. Turnbull, Chem. Rev., 88, 297 (1988).CrossRefGoogle Scholar
  4. 4.
    T. Gilchrist, G. E. Gymer, A. R. Katritzky, and J. A. Boulton, Adv. Heterocycl. Chem., 16, 33 (1974).CrossRefGoogle Scholar
  5. 5.
    D. I. Patei and R. K. Smalley, J. Chem. Soc. Perkin I, 2587 (1984).Google Scholar
  6. 6.
    B. Loubinoux, J. N. Colin, and S. Tabbache, J. Heterocycl. Chem., 21, 1669 (1984).CrossRefGoogle Scholar
  7. 7.
    B. K. Sanghvi, G. D. Bhattacharya, S. S. Kini, S. B. Matsumoto, W. B. Larson, R. K. Jolley, G. R. Robins, and G. R. Revankar, J. Med. Chem., 33, 336 (1990).CrossRefGoogle Scholar
  8. 8.
    K. M. Banu and A. Dinakar, C. Ananthanarayanan, Indian J. Pharm. Sci., 4, 202 (1999).Google Scholar
  9. 9.
    M. D. Chen, S. J. Lu, G. P. Yuag, S. Y. Yang, and X. L. Du, Heterocycl. Commun., 6, 421 (2000).Google Scholar
  10. 10.
    E. A. Sherement, R. I. Tomanov, E. V. Trukhin, and V. M. Berestovitskaya, Russ. J. Org. Chem., 40, 594 (2004).CrossRefGoogle Scholar
  11. 11.
    W. Pfleiderer and K. H. Schündhütte, Liebigs Ann. Chem., 612, 158 (1958).CrossRefGoogle Scholar
  12. 12.
    A. A.-H. Abdel-Rahman, A. E.-S. Abdel-Megied, M. A. M. Hawata, E. R. Kasem, and M. T. Shabaan, Monatsh. Chem., 138, 889 (2007).CrossRefGoogle Scholar
  13. 13.
    R. S. Farag, A. S. Shalaby, G. A. El-Baroty, and N. A. Ibrahim, Phytother. Res., 18, 30(2004).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  1. 1.Department of Organic Chemistry, College of PharmacyMisr University for Science and Technology6th October CityEgypt
  2. 2.Department of Chemistry, Faculty of ScienceMenoufia UniversityShebin El-KoamEgypt

Personalised recommendations