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Chemistry of Heterocyclic Compounds

, Volume 46, Issue 9, pp 1105–1108 | Cite as

Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives

  • A. Sh. El-Etrawy
  • A. A.-H. Abdel-RahmanEmail author
Article

Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.

Keywords

pyrimidine derivatives 1,2,3-triazoles anti hepatitis A virus cycloaddition 

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Copyright information

© Springer Science+Business Media, Inc. 2010

Authors and Affiliations

  1. 1.Department of Organic Chemistry, College of PharmacyMisr University for Science and Technology6th October CityEgypt
  2. 2.Department of Chemistry, Faculty of ScienceMenoufia UniversityShebin El-KoamEgypt

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