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4-hydroxy-2-quinolones. 178*. irreversible chemical modification of chinoxicaine at the position 4 of the quinolone ring

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Chemistry of Heterocyclic Compounds Aims and scope

While continuing our investigation in improving the pharmaceutical activities of the local anesthetic Chinoxicaine we have studied the irreversible replacement of its 4-OH group for bioisosteric fragments. For this purpose the synthesis of a series of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-(diethylamino)ethylamide hydrochlorides has been carried out. The experimental data of the local anesthetic properties of the compounds obtained are given and discussed.

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References

  1. I. V. Ukrainets, N. L. Bereznyakova, L. A. Grinevich, V. E. Kuz'min, and A. G. Artemenko, Khim. Geterotsikl. Soedin., 868 (2010). [Chem. Heterocycl. Comp., 46, 699 (2010)].

    Google Scholar 

  2. I. V. Ukrainets and P. A. Bezuglyi, US Pat. 6340692 (2002). http://espacenet.com

  3. I. V. Ukrainets, V. V. Kravtsova, A. A. Tkach, and V. B. Rybakov, Khim. Geterotsikl. Soedin., 875 (2009). [Chem. Heterocycl. Comp., 45, 698 (2009)].

    Google Scholar 

  4. I. V. Ukrainets, V. V. Kravtsova, A. A. Tkach, V. I. Mamchur, and E. Yu. Kovalenko, Khim. Geterotsikl. Soedin., 113 (2010). [Chem. Heterocycl. Comp., 46, 96 (2010)].

    Google Scholar 

  5. F. D. King (editor), Medicinal Chemistry: Principles and Practice, Royal Society of Chemistry, Cambridge (2002).

    Google Scholar 

  6. I. V. Ukrainets, L. V. Sidorenko, O. V. Gorokhova, and N. A. Jaradat, Khim. Geterotsikl. Soedin., 542 (2006). [Chem. Heterocycl. Comp., 42, 475 (2006)].

    Google Scholar 

  7. I. V. Ukrainets, O. V. Gorokhova, L. V. Sidorenko, and N. L. Bereznyakova, Khim. Geterotsikl. Soedin., 69 (2007). [Chem. Heterocycl. Comp., 43, 58 (2007)].

    Google Scholar 

  8. I. V. Ukrainets, A. A. Tkach, V. V. Kravtsova, and A. V. Turov, Khim. Geterotsikl. Soedin., 1799 (2007). [Chem. Heterocycl. Comp., 43, 1525 (2007)].

    Google Scholar 

  9. I. V. Ukrainets, V. V. Kravtsova, A. A. Tkach, and G. Sim, Khim. Geterotsikl. Soedin., 233 (2008). [Chem. Heterocycl. Comp., 44, 173 (2008)].

    Google Scholar 

  10. I. V. Ukrainets, A. A. Tkach, V. V. Kravtsova, and S. V. Shishkina, Khim. Geterotsikl. Soedin., 847 (2008). [Chem. Heterocycl. Comp., 44, 677 (2008)].

    Google Scholar 

  11. I. V. Ukrainets, A. A. Tkach, V. V. Kravtsova, and S. V. Shishkina, Khim. Geterotsikl. Soedin., 59 (2009). [Chem. Heterocycl. Comp., 45, 48 (2009)].

    Google Scholar 

  12. I. V. Ukrainets, S. G. Taran, O. V. Gorokhova, N. A. Marusenko, S. N. Kovalenko, A. V. Turov, N. I. Filimonova, and S. M. Ivkov, Khim. Geterotsikl. Soedin., 195 (1995). [Chem. Heterocycl. Comp., 31, 167 (1995)].

    Google Scholar 

  13. V. I. Mamchur, E. Yu. Kovalenko, G. I. Stepanyuk, and A. A. Stolyarchuk, Experimental (Preclinical) Study of Novel Local Anesthetic Agents: Recommended Methods, State Pharmaceutical Center, Ukraine Ministry of Health, Kiev (2003).

    Google Scholar 

  14. I. V. Ukrainets, A. A. Davidenko, E. V. Mospanova, L. V. Sidorenko, and Ye. N. Svechnikova, Khim. Geterotsikl. Soedin., 706 (2010). [Chem. Heterocycl. Comp., 46, 559 (2010)].

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Authors and Affiliations

  1. National University of Pharmacy, Kharkiv, 61002, Ukraine

    I. V. Ukrainets, A. A. Tkach & V. V. Kravtsova

  2. Dnepropetrovsk State Medical Academy, Dnepropetrovsk, 49044, Ukraine

    V. I. Mamchur & E. Yu. Kovalenko

Authors
  1. I. V. Ukrainets
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  2. A. A. Tkach
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  3. V. V. Kravtsova
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  4. V. I. Mamchur
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  5. E. Yu. Kovalenko
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Corresponding author

Correspondence to I. V. Ukrainets.

Additional information

* For Communication 177, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1050-1057, July, 2010.

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Ukrainets, I.V., Tkach, A.A., Kravtsova, V.V. et al. 4-hydroxy-2-quinolones. 178*. irreversible chemical modification of chinoxicaine at the position 4 of the quinolone ring. Chem Heterocycl Comp 46, 850–855 (2010). https://doi.org/10.1007/s10593-010-0593-z

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  • DOI: https://doi.org/10.1007/s10593-010-0593-z

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