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4-Hydroxy-2-quinolones. 177*. Study of a structure-diuretic activity relationship in a series of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid N-R-amides

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Chemistry of Heterocyclic Compounds Aims and scope

With the aim of deducing a structure-biological dependence we have carried out the synthesis of quinoline-3-carboxylic acid N-R-amides with a p-methoxyphenyl substituent in the amide part of the molecule. The effects of the compounds prepared on the excretory function of the kidney are discussed. Using a system of simplex descriptors and the method of tree type classification a QSAR model has been constructed which is suitable for prediction of the diuretic activity of novel quinolinecarboxylic acid N-R-amides.

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Authors and Affiliations

  1. National University of Pharmacy, Kharkiv, 61002, Ukraine

    I. V. Ukrainets, N. L. Bereznyakova & L. A. Grinevich

  2. A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences, Odessa, 65080, Ukraine

    V. E. Kuz’min & A. G. Artemenko

Authors
  1. I. V. Ukrainets
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  2. N. L. Bereznyakova
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  3. L. A. Grinevich
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  4. V. E. Kuz’min
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  5. A. G. Artemenko
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Correspondence to I. V. Ukrainets.

Additional information

*For Communication 176, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 868-881, June, 2010.

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Ukrainets, I.V., Bereznyakova, N.L., Grinevich, L.A. et al. 4-Hydroxy-2-quinolones. 177*. Study of a structure-diuretic activity relationship in a series of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid N-R-amides. Chem Heterocycl Comp 46, 699–710 (2010). https://doi.org/10.1007/s10593-010-0572-4

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  • DOI: https://doi.org/10.1007/s10593-010-0572-4

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