Recyclization of 2-(2,5-dioxopyrrolidin-1-yl)-guanidine under the action of aliphatic amines. a novel method for the synthesis of 3-(5-amino-1h-1,2,4-triazol-3-yl)propanoic acid amides
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We have previously reported  that 2-(2,5-dioxopyrrolidin-1-yl)guanidine hydrochloride (1), prepared by fusion of the aminoguanidine hydrochloride (2) with succinic anhydride, rearranges to 3-(5-amino-1H-1,2,4-triazol-3-yl)propanoic acid when heated in aqueous alkali solution.
Keywordsamides amines 3-(5-amino-1H-1,2,4-triazol-3-yl)propanoic acid 2-(2,5-dioxopyrrolidin-1-yl)- guanidine recyclization
- 1.A. V. Chernysheva, Diss. Cand. Chem. Sci., Ivanovo (2009).Google Scholar