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New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Direct phenylation of the nitrogen atom in pyridines was noted in a study of the ion-molecule reactions of free nucleogenic phenyl cations generated by β-decay of tritium in labeled benzene. A one-step synthesis of unreported biologically active tritium-labeled N-phenyl-2,6-lutidinium and 2,4,6-collidi-nium salts. Steric factors, which significantly reduce the yield in the case of sym-collidine, play a major role in the direct phenylation of nitrogen.

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Authors and Affiliations

  1. Natural Sciences Institute, Perm State University, Perm, 614990, Russia

    N. E. Shchepina

  2. St. Petersburg State University, St. Petersburg, 199034, Russia

    V. V. Avrorin

  3. M. V. Lomonosov Moscow State University, Moscow, 119991, Russia

    G. A. Badun & V. M. Fedoseev

  4. James Madison University, Harrisonburg, VA, USA

    S. B. Lewis

Authors
  1. N. E. Shchepina
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  2. V. V. Avrorin
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  3. G. A. Badun
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  4. V. M. Fedoseev
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  5. S. B. Lewis
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Corresponding author

Correspondence to N. E. Shchepina.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 692-698, May, 2010.

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Shchepina, N.E., Avrorin, V.V., Badun, G.A. et al. New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives. Chem Heterocycl Comp 46, 547–552 (2010). https://doi.org/10.1007/s10593-010-0544-8

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  • DOI: https://doi.org/10.1007/s10593-010-0544-8

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