3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl- and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.
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For Communication 21, see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No.4, 624-629, April 2010.
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Matiychuk, V.S., D.Obushak, N., Pidlypnyi, N.I. et al. Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds 22.* 3-Aryl-2-chloropropanal in the synthesis of N-Aryl-5-(R-benzyl)-1,3-thiazole-2-amines. Chem Heterocycl Comp 46, 495–499 (2010). https://doi.org/10.1007/s10593-010-0537-7
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DOI: https://doi.org/10.1007/s10593-010-0537-7