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A convenient route for the synthesis of some new bi- and triheterocondensed uracils

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Chemistry of Heterocyclic Compounds Aims and scope

Some bifunctional heterocyclic systems having vicinal chlorocyano, chloroacetyl, and chloro-ethoxycarbonyl groups in their structures reacted with 6-amino-1,3-dimethyluracil to afford novel triheterocyclic systems having a pyrimidinedione moiety. Enaminones and α-cyanocinnamic acid derivatives in this reaction gave pyrido[2,3-d]pyrimidinediones. The antimicrobial activity of some new synthesized triheterocyclic systems was studied.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, A. R., Egypt

    M. Abdel-Megid

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  1. M. Abdel-Megid
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Correspondence to M. Abdel-Megid.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 405-414, March, 2010.

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Abdel-Megid, M. A convenient route for the synthesis of some new bi- and triheterocondensed uracils. Chem Heterocycl Comp 46, 316–324 (2010). https://doi.org/10.1007/s10593-010-0507-0

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  • DOI: https://doi.org/10.1007/s10593-010-0507-0

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