Skip to main content
SpringerLink
Log in

Synthesis and spectral analysis of novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones are synthesized by the multicomponent cyclocondensation reaction of the appropriate 2-amino-4,6-diarylpyrimidines, benzaldehyde, and thioglycolic acid catalyzed by dicyclohexylcarbodiimide. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, 1H and 13C NMR spectroscopic data.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. J. Andres, J. J. Bronson, S. V. D’Andrea, M. S. Deshpande, P. J. Falk, K. A. Grant-Young, W. E. Harte, Hsu-Tso Ho, P. F. Misco, J. G. Robertson, D. Stock, Yaxiong Sun, and A. W. Walsh, Bioorg. Med. Chem. Lett., 10, 715 (2000).

    Article  CAS  Google Scholar 

  2. G. K. Nampurath, S. P. Mathew, Vivek Khanna, R. T. Zachariah, Suman Kanji, and Mallikarjuna Rao Chamallamudi, Chem. Biol. Interact., 171, 363 (2008).

    Article  CAS  Google Scholar 

  3. R. Ottanà, R. Maccari, R. Ciurleo, M. G. Vigorita, A. M. Panico, V. Cardile, F. Garufi, and S. Ronsisvalle, Bioorg. Med. Chem., 15, 7618 (2007).

    Article  Google Scholar 

  4. J. N. Narendra Sharath Chandra, Manish Malviya, C. T. Sadashiva, M. N. Subhash, and K. S. Rangappa, Neurochem. Int., 52, 376 (2008).

    Article  Google Scholar 

  5. V. Kishore, N. K. Narain, S. Kumar, and S. S. Parmar, Pharmacol. Res. Commun., 8, 43 (1976).

    Article  CAS  Google Scholar 

  6. B. B. Newbould, Br. J. Pharmacol. Chemother., 24, 632 (1965).

    CAS  Google Scholar 

  7. P. Schauer, M. Likar, M. Tisler, A. Krbavcic, and A. Pollak, Pathol. Microbiol., 28, 382 (1965).

    CAS  Google Scholar 

  8. V. N. Chaubey and H. Singh, Bull. Chem. Soc. Jpn., 43, 2233 (1970).

    Article  Google Scholar 

  9. E. B. Akerblom, J. Med. Chem., 17, 609 (1974).

    Article  CAS  Google Scholar 

  10. M. D. Litvinchuk, Farmakol. Toksikol., 26, 725 (1963).

    CAS  Google Scholar 

  11. A. K. Dimri and S. S. Parmar, J. Heterocycl. Chem., 15, 335 (1978).

    Article  CAS  Google Scholar 

  12. S. S. Parmar, C. Dwivedi, A. Chaudhari, and T. K. Gupta, J. Med. Chem., 15, 99 (1972).

    Article  CAS  Google Scholar 

  13. S. P. Singh, S. S. Parmar, Krishna Raman, and V. I. Stenberg, Chem. Rev., 81, 175 (1981).

    Article  CAS  Google Scholar 

  14. P. D. Jacobus, Van Veldhoven, C. W. Lisa, Chang, J. Künzel, T. Mulder-Krieger, R. Struensee-Link, M. W. Beukers, J. Brussee, and I. P. Ijzerman, Bioorg. Med. Chem., 16, 2741 (2008).

    Article  Google Scholar 

  15. T. V. Hughes, S. L. Emanuel, A. K. Beck, S. K. Wetter, P. J. Connolly, Prabha Karnachi, Michael Reuman, Jabed Seraj, AR Fuentes-Pesquera, R. H. Gruninger, S. A. Middleton, Ronghui Lin, J. M. Davis, and D. F. C. Moffat, Bioorg. Med. Chem. Lett., 17, 3266 (2007).

    Article  CAS  Google Scholar 

  16. M. T. Chhabria, H. G. Bhatt, H. G. Raval, and P. M. Oza, Bioorg. Med. Chem. Lett., 17, 1022 (2007).

    Article  CAS  Google Scholar 

  17. K. L. Sayle, J. F. Bentley, T. Boyle, A. H. Calvert, Yuzhu Cheng, N. J. Curtin, J. A. Endicott, B. T. Golding, I. R. Hardcastle, P. Jewsbury, V. Mesguiche, D. R. Newell, M. E. M. Noble, R. J. Parsons, D. J. Pratt, L. Z. Wang, and R. J. Griffin, Bioorg. Med. Chem. Lett., 13, 3079 (2003).

    Article  CAS  Google Scholar 

  18. A. Pastor, R. Alajarin, J. J. Vaquero, J. Alvarez-Builla, M. Fau de Casa-Juana, C. Sunkel, J. G. Priego, I. Fonseca, and J. Sanz-Aparicio, Tetrahedron, 50, 8085 (1994).

    Article  CAS  Google Scholar 

  19. M. S. Youssouf, P. Kaiser, G. D. Singh, S. Singh, S. Bani, V. K. Gupta, N. K. Satti, K. A. Suri, and R. K. Johri, Int. Immunopharmacol., 8, 1049 (2008).

    Article  CAS  Google Scholar 

  20. C. Gasse, D. Douguet, V. Huteau, G. Marchal, H. Munier-Lehmann, and S. Poche, Bioorg. Med. Chem., 16, 6075 (2008).

    Article  CAS  Google Scholar 

  21. M. Gopalakrishnan, P. Sureshkumar, V. Kanagarajan, and J. Thanusu, J. Sulf. Chem., 28, 383 (2007).

    Article  CAS  Google Scholar 

  22. M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, and V. Kanagarajan, J. Enz. Inhib. Med. Chem., 23, 974 (2008).

    Article  CAS  Google Scholar 

  23. M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, and V. Kanagarajan, J. Enz. Inhib. Med. Chem., 23, 347 (2008).

    Article  CAS  Google Scholar 

  24. M. Gopalakrishnan, J. Thanusu, and V. Kanagarajan, Med. Chem. Res., 16, 392 (2007).

    Article  CAS  Google Scholar 

  25. M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, V. Kanagarajan, R. Govindaraju, and G. Jayasri, J. Enz. Inhib. Med. Chem., 22, 709 (2007).

    Article  CAS  Google Scholar 

  26. W. Guthrie and X. P. Wang, Can. J. Chem., 69, 339 (1991).

    Article  CAS  Google Scholar 

  27. S. Kothari, M. Singhal, D. Vijayvergia, R. Vyas, and B. L. Verma. J. Indian Chem. Soc., 77, 329 (2000).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608002, Tamil Nadu, India

    M. Gopalakrishnan, J. Thanusu & V. Kanagarajan

Authors
  1. M. Gopalakrishnan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Thanusu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Kanagarajan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Gopalakrishnan.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, 1906–1912, December, 2009.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gopalakrishnan, M., Thanusu, J. & Kanagarajan, V. Synthesis and spectral analysis of novel 3-(4,6-diarylpyrimidin-2-yl)-2-phenylthiazolidin-4-ones. Chem Heterocycl Comp 45, 1539–1544 (2009). https://doi.org/10.1007/s10593-010-0462-9

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-010-0462-9

Keywords

Search

Navigation