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Synthesis and biological activity of new 2-[(3-aminopropyl)dimethyl-silyl]-5-trialkylgermylfurans

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Chemistry of Heterocyclic Compounds Aims and scope

New highly cytotoxic 3-aminopropyl derivatives of 2-dimethylsilyl-5-trialkylgermylfuran (IC50 1−3 μg⋅ml−1) have been prepared by hydrosilylation of heterocyclic N-allylamines with the corresponding hydrosilane in the presence of Speier’s catalyst. The influence of the amine structure and alkyl substituent at the germanium atom on the cytotoxicity has been investigated.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia

    L. Ignatovich, V. Romanovs, I. Shestakova, I. Domrachova, J. Popelis & E. Lukevics

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  1. L. Ignatovich
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  2. V. Romanovs
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  3. I. Shestakova
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  4. I. Domrachova
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  5. J. Popelis
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  6. E. Lukevics
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Correspondence to L. Ignatovich.

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Deceased. (E. Lukevics)

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1791–1799, November, 2009.

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Ignatovich, L., Romanovs, V., Shestakova, I. et al. Synthesis and biological activity of new 2-[(3-aminopropyl)dimethyl-silyl]-5-trialkylgermylfurans. Chem Heterocycl Comp 45, 1441–1448 (2009). https://doi.org/10.1007/s10593-010-0447-8

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  • DOI: https://doi.org/10.1007/s10593-010-0447-8

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