Synthesis and investigation of the biological properties of 6-oxa-8α-analogs of steroid estrogens containing a methyl group at C-4
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4-Methyl-substituted 6-oxa-8α-analogs of steroid estrogens have been synthesized and the 1H and 13C NMR signals of these compounds have been completely assigned. It is shown that introduction of a methyl group in position 4 of steroids of the given stereochemical series leads to the loss of uterotropic and hypertriglyceridemic effects of the modified compounds. Steroids with these properties may have promise for the creation of vectors for transport into target organs of estrogens of other classes of compounds and inhibitors of enzymes responsible for the metabolism of hormones.
Keywords6-oxa-8α-analogs of steroid estrogens their biological properties NMR spectroscopy
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