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Catalytic hydrogenation of methyl esters of some 1h-pyrazoline-3-carboxylic acids

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Chemistry of Heterocyclic Compounds Aims and scope

Hydrogenation over Raney nickel of the methyl ester of 1H-pyrazoline-3-carboxylic acid and also of its 4-phenyl and 5-methoxycarbonyl-substituted analogs, leads respectively to 3-aminopyrrolidin-2-one, its 4-phenyl- and 5-methoxycarbonyl derivatives, predominantly to the trans isomer. Under the same conditions 1-amino-4-methoxycarbonylpyrrolidin-2-one was obtained from 3,4-di(methoxycarbonyl)-1H-pyrazoline, but 3,4,5-tri(methoxycarbonyl)-1H-pyrazoline did not react.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, 450054, Russia

    V. A. Gorpinchenko, D. V. Petrovcx, S. S. Lozhkin, E. G. Galkin & V. A. Dokichev

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  1. V. A. Gorpinchenko
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  2. D. V. Petrovcx
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  3. S. S. Lozhkin
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  4. E. G. Galkin
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  5. V. A. Dokichev
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Corresponding author

Correspondence to D. V. Petrovcx.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1500-1506, October, 2009.

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Gorpinchenko, V.A., Petrovcx, D.V., Lozhkin, S.S. et al. Catalytic hydrogenation of methyl esters of some 1h-pyrazoline-3-carboxylic acids. Chem Heterocycl Comp 45, 1202–1207 (2009). https://doi.org/10.1007/s10593-010-0408-2

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  • DOI: https://doi.org/10.1007/s10593-010-0408-2

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