Synthesis of 7-(3-piperidyl)-[1,6]naphthyridine and 7-(4-pipe-ridyl)[1,6]naphthyridine

  • D. A. KovalskiyEmail author
  • V. P. Perevalov

7-(3-Piperidyl)- and 7-(4-piperidyl)[1,6]naphthyridines have been synthesized from 2-methylpyridine-3-carbaldehyde cyclohexylimine and the methylmethoxycarboxamides (Weinreb amides) of N-Boc- substituted nipecotic and isonipecotic acids.


Weinreb amide isoquinoline naphthyridine piperidine 


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    D. A. Kovalskiy and V. P. Perevalov, Khim. Geterotsikl. Soedin., 1204 (2009). [Chem. Heterocycl. Comp., 45, 957 (2009)].Google Scholar
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    Q. Huang and R. Larock, J. Org. Chem., 67, 3437 (2002).CrossRefGoogle Scholar
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    A. Numata and Y. Kondo, Synthesis, 306 (1999).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.Asinex LtdMoscowRussia
  2. 2.D. Mendeleev University of Chemical Technology of RussiaMoscowRussia

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