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Synthesis of novel 1,2-functionally-substituted 6,7-dimethoxy-4-spirocyclo-pentanetetrahydroisoquinolines

  • A. A. AghekyanEmail author
  • E. A. Arakelyan
  • G. A. Panosyan
  • A. G. Khachatryan
  • E. A. Markaryan
Article

1-[(3,4-Dimethoxyphenyl)cyclopentyl]methylamine has been used in the synthesis of 6,7-dimethoxy-4-spirocyclopentane-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid N-methylamide which is employed in the preparation of novel derivatives with substituents in positions 1,2,6, and 7.

Keywords

1-[(3,4-dimethoxyphenyl)cyclopentyl]methylamine spirocyclopentane tetrahydroiso-quinoline reduction 

References

  1. 1.
    B. Merck, Liebigs Ann. Chem., 66, 125 (1848).Google Scholar
  2. 2.
    G. L. Grunewald, F. A. Romero, and K. R. Griscione, J. Med. Chem., 48, 134 (2005).CrossRefGoogle Scholar
  3. 3.
    N. De la Figuera, S. Fiol, J.-C. Fernandez, P. Forns, D. F. Fernez, and F. Alberio, Synth. Lett., 1903 (2006).Google Scholar
  4. 4.
    A. A. Agekyan, L. Sh. Pirdzhanov, and E. A. Markaryan, Arm. Khim. Zh., 37, 503 (1984).Google Scholar
  5. 5.
    G. K. Airapetyan, Zh. S. Arustamyan, R. E. Markaryan, E. M. Arzanunts, L. M. Sarkisyan, A. V. Pogosyan, and E. A. Markaryan, Khim.-Farm. Zh., 24, No. 5, 33 (1990).Google Scholar
  6. 6.
    A. L. Mndzhoyan, E. A. Markaryan, Zh. S. Arustamyan, and E. S. Marashyan, Khim. Geterotsikl. Soedin., 637 (1971). [Chem. Heterocycl. Comp., 7, 596 (1971)].Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • A. A. Aghekyan
    • 1
    Email author
  • E. A. Arakelyan
    • 1
  • G. A. Panosyan
    • 1
  • A. G. Khachatryan
    • 1
  • E. A. Markaryan
    • 1
  1. 1.A. L. Mnjoyan Institute of Fine Organic ChemistryNational Academy of Sciences of the Republic of ArmeniaYerevanArmenian Republic

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