Synthesis of methyl 6-aryl-5-(1H-benzimidazol-2-yl)-2-methylnicotinates

  • I. B. Dzvinchuk
  • M. O. Lozinskii

A three-component cyclocondensation of 4-(dimethylamino)benzaldehyde, 2-phenacyl-1H-benz-imidazoles, and methyl 3-aminobut-2-enoate in refluxing acetic acid occurs via a Hantzsch type reaction and is accompanied by the loss of N,N-dimethylaniline to give the previously unknown methyl 6-aryl-5-(1H-benzimidazol-2-yl)-2-methylnicotinates.


benzimidazoles pyridines aromatization dearylation Hantzsch reaction 


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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.Institute of Organic Chemistry National Academy of Sciences of UkraineKievUkraine

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