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4-Hydroxy-2-quinolones 166*. Synthesis, isomerism, and antitubercular activity of 3-arylaminomethylene-quinoline-2,4-(1H,3H)-diones

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Chemistry of Heterocyclic Compounds Aims and scope

Condensation of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbaldehydes, thioglycolic acid (or methyl thioglycolate), and anilines does not lead to the synthesis of the corresponding thiazolidinylquinolones because the Schiff bases so formed exist exclusively in a form inert to enamine thioglycolates. 1H NMR spectroscopy showed that the main components of the isolated 3-arylaminomethylenequinoline-2,4-(1H,3H)-diones are E-isomers. The results of a study of the antitubercular properties of the compounds obtained are presented.

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Correspondence to I. V. Ukrainets.

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*For Communication 165 see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1015–1022, July, 2009.

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Ukrainets, I.V., Yangyang, L., Tkach, A.A. et al. 4-Hydroxy-2-quinolones 166*. Synthesis, isomerism, and antitubercular activity of 3-arylaminomethylene-quinoline-2,4-(1H,3H)-diones. Chem Heterocycl Comp 45, 802–808 (2009). https://doi.org/10.1007/s10593-009-0356-x

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