2-Alkyl-3-(indol-3-yl)-1,3-dihydroisoindol-1-ones have been obtained in good yield on amidoalkylation of indoles with 2-alkyl-3-hydroxyphthalides in chloroform at room temperature in the presence of catalytic quantities of boron trifluoride etherate. When a substituent is present at position 3 of the indole, attack is directed to position 2 of the indole nucleus.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 847-852, June, 2009.
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Andryukhova, N.P., Pozharskaya, O.A., Golubeva, G.A. et al. Synthesis of 2-alkyl-3-(indol- 2(or 3)-yl)-1,3-dihydroisoindol- 1-ones by amidoalkylation. Chem Heterocycl Comp 45, 672–676 (2009). https://doi.org/10.1007/s10593-009-0333-4
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DOI: https://doi.org/10.1007/s10593-009-0333-4