Chemistry of Heterocyclic Compounds

, Volume 45, Issue 3, pp 361–364 | Cite as

one-pot synthesis of pyrrolo-[3,4-d]isoxazoline-4,6-diones via nitrile oxides

  • J. RajputEmail author
  • B. Singh
  • K. K. Singal

1,3-Dipolar cycloaddition of nitrile oxides generated in situ in the presence of variously substituted N-arylmaleimides and N-benzylmaleimide provides new pyrrolo[3,4-d]izoxazoline-4,6-diones in good yields. The whole procedure could be performed in a practical and efficient one-pot operation. All the cycloadducts were isolated in excellent yields and identified by spectral studies.


maleimides nitrile oxides regiospecific 1;3-dipolar cycloaddition 


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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.Department of ChemistryDr. B. R. Ambedkar National Institute of TechnologyJalandharIndia
  2. 2.Department of ChemistryPunjabi UniversityPatialaIndia

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