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Chemistry of Heterocyclic Compounds

, Volume 45, Issue 3, pp 357–360 | Cite as

Reaction of 2-alkylthio-6-amino-pyrimidin-4(3H)-ones with ethyl bromopyruvate. Synthesis of furo-[2,3-d]-pyrimidine and furo[3,2-e]imidazo-[1,2-c]pyrimidine carboxylates

  • V. Masevicius
  • G. Petraityte
  • S. TumkeviciusEmail author
Article

Reaction of 2-alkylthio-6-aminopyrimidin-4(3H)-ones with ethyl bromopyruvate to give ethyl 2-alkyl-thio-4-aminofuro[2,3-d]pyrimidine-5-carboxylates has been shown to proceed under neutral or acidic conditions. The obtained furo[2,3-d]pyrimidines underwent further cyclocondensation reaction with ethyl bromopyruvate to afford diethyl 5-alkylthiofuro[3,2-e]imidazo[1,2-c]pyrimidine-2,9-dicarboxy-lates.

Keywords

furo[3,2-e]imidazo[1,2-c]pyrimidines furo[2,3-d]pyrimidines pyrimidin-4(3H)-ones cyclization 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  1. 1.Vilnius University Department of Organic ChemistryVilniusLithuania

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