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Chemistry of Heterocyclic Compounds

, Volume 45, Issue 2, pp 169–175 | Cite as

4-Hydroxy-2-quinolones. 152*. 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline and its biologically active derivatives

  • I. V. UkrainetsEmail author
  • A. A. Tkach
  • Liu Yang Yang
Article

A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.

Keywords

3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinolines acetoacetic ester hydrazides hydrazones 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids antitubercular activity X-ray structural analysis 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • I. V. Ukrainets
    • 1
    Email author
  • A. A. Tkach
    • 1
  • Liu Yang Yang
    • 1
  1. 1.National University of PharmacyKharkivUkraine

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