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Chemistry of Heterocyclic Compounds

, Volume 45, Issue 1, pp 42–47 | Cite as

Condensed isoquinolines 33*. Synthesis of 1′-R-spiro-[7H,8H-2a,7a-diazacyclopenta-[fg]naphthacene-2,4′-(1′H)-pyridine]-1,8(2H)-diones

  • L. M. Potikha
  • R. M. Gutsul
  • V. A. Kovtunenko
Article

Heating 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one with isonicotinoyl chloride in pyridine gives 6-isonicotinoyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one. The 1-alkyl-4[(11-oxo-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-6-yl)carbonyl]pyridinium iodides obtained by alkylation of 6-isonicotinoyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one using alkyl iodides in the presence of NaH are converted to 1′-R-spiro[7H,8H-2a,7a-diazacyclopenta[fg]naphthacene-2,4′(1′H)-pyridine]-1,8(2H)-diones. The chemical and spectroscopic properties of the spiro compounds obtained were studied.

Keywords

2a,7a-diazacyclopenta[fg]naphthacene enamines isoquino[3,2-b]quinazoline spiro-1,4-dihydropyridine alkylation acylation 

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Copyright information

© Springer Science+Business Media, Inc. 2009

Authors and Affiliations

  • L. M. Potikha
    • 1
  • R. M. Gutsul
    • 1
  • V. A. Kovtunenko
    • 1
  1. 1.Taras Shevchenko National UniversityKievUkraine

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