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Synthesis of new 1-substituted 4-(2-phenylquinazolin-4-yl)-and 4-(2-phenylquinazolin-4-ylidene) thiosemicarbazides

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Chemistry of Heterocyclic Compounds Aims and scope

Two new 1-substituted 4-(2-phenylquinazolin-4-yl)-and 4-(2-phenylquinazolin-4-ylidene) thio-semicarbazides were formed by a multistep domino reaction of imidoyl isothiocyanate derivative with 1,1-di-R-hydrazine in acetone solution. Application of hydrazine hydrate under the same reaction conditions afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(propen-2-yl)-1-(propan-2-ylidene) thio-semicarbazide via a six-step triple-component domino reaction.

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Authors and Affiliations

  1. Department of Mathematics and Physical Sciences, Faculty of Engineering Suez Canal University, Port-Said, Egypt

    W. Fathalla

  2. Centre for Syntheses at Sustainable Conditions and Their Management, Faculty of Science, Masaryk University, Brno, Czech Republic

    P. Pazdera

Authors
  1. W. Fathalla
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  2. P. Pazdera
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Correspondence to W. Fathalla.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1688–1693, November, 2008.

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Fathalla, W., Pazdera, P. Synthesis of new 1-substituted 4-(2-phenylquinazolin-4-yl)-and 4-(2-phenylquinazolin-4-ylidene) thiosemicarbazides. Chem Heterocycl Comp 44, 1374–1378 (2008). https://doi.org/10.1007/s10593-009-0191-0

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  • DOI: https://doi.org/10.1007/s10593-009-0191-0

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