Heterocyclic analogs of combretastatin A-4
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A novel route is proposed for the synthesis of heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.
Keywordsacetylenes combretastatin A-4 heterocyclization homogeneous catalysis cross-coupling
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