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Chemistry of Heterocyclic Compounds

, Volume 44, Issue 10, pp 1257–1261 | Cite as

Heterocyclic analogs of combretastatin A-4

  • S. F. Vasilevsky
  • M. P. Davydova
  • G. A. Tolstikov
Article

A novel route is proposed for the synthesis of heterocyclic analogs of the naturally occurring combretastatin A-4 based on the reaction of α-acetylenic ketones with polyfunctional nucleophiles (hydroxylamine, hydrazine, guanidine). Previously unknown combretastatin A-4 analogs with azole and azine bridges were obtained.

Keywords

acetylenes combretastatin A-4 heterocyclization homogeneous catalysis cross-coupling 

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • S. F. Vasilevsky
    • 1
  • M. P. Davydova
    • 1
  • G. A. Tolstikov
    • 2
  1. 1.Institute of Chemical Kinetics and CombustionSiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  2. 2.N. N. Vorozhtsov Institute for Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussia

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