Skip to main content
SpringerLink
Log in

A new method for the synthesis of 5-bromo(aryl)methylene-substituted hydantoins

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

It has been shown that bromination of 5-aryl-5-benzylidene-3,5-dihydro-4H-2-methylthioimidazol-4-one in methylene chloride at room temperature leads to the addition of bromine at the double bond, but the the reaction of 5-aryl-3,5-dihydro-4H-2-methylthio-5-(2-pyridylmethylene)imidazol-4-one gave complex compound of the starting materials. After boiling both of the compounds obtained in ethanol the corresponding 5-[bromo(aryl)methylene]imidazolidine-2,4-diones were obtained.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. R. Lewis, Nat. Prod. Rep., 17, 57 (2000).

    Article  CAS  Google Scholar 

  2. T. Lindel and H. Hoffmann, Tetrahedron Lett., 38, 8935 (1997).

    Article  CAS  Google Scholar 

  3. J. Charton, A. C. Gassiot, S. Girault-Mizzi, M.-A. Debreu-Fontaine, P. Melnyk, and Ch. Sergheraert, Bioorg. Med. Chem. Lett., 15, 4833 (2005).

    Article  CAS  Google Scholar 

  4. A. Degterev, Z. Huang, M. Boyce, Y. Li, P. Jagtap, N. Mizushima, G. D. Cuny, T. Mitchison, M. Moskowitz, and J. Yuan, Nat. Chem. Biol., 1, 112 (2005).

    Article  CAS  Google Scholar 

  5. A. I. Khodair, Carbohydr. Res., 331, 445 (2001).

    Article  CAS  Google Scholar 

  6. D. A. Hahn, M. J. McLean, and H. T. Murphy, J. Am. Chem. Soc., 60, 1927 (1938).

    Article  CAS  Google Scholar 

  7. M. J. McLean and D. R. Seeger, J. Am. Chem. Soc., 66, 2020 (1944).

    Article  Google Scholar 

  8. A. G. Mazhuga, E. K. Beloglazkina, S. Z. Vatsadze, N. A. Frolova, and N. V. Zyk, Izv. AN, Ser. Khim., 2734 (2004).

  9. G. G. Muccioli, J. H. Poupaert, J. Wouters, B. Norberg, W. Poppitz, G. K. E. Scriba, and D. M. Lambert, Tetrahedron, 59, 1301 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Moscow, 119992, Russia

    R. L. Antipin, E. K. Beloglazkina, A. G. Magouga, A. N. Chernysheva & N. V. Zyk

Authors
  1. R. L. Antipin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. K. Beloglazkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. G. Magouga
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. N. Chernysheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. V. Zyk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. G. Magouga.

Additional information

Dedicated to Academician B. A. Trofimov on his 70th jubilee.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, 1406–1408, September, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Antipin, R.L., Beloglazkina, E.K., Magouga, A.G. et al. A new method for the synthesis of 5-bromo(aryl)methylene-substituted hydantoins. Chem Heterocycl Comp 44, 1135–1137 (2008). https://doi.org/10.1007/s10593-008-0167-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-008-0167-5

Keywords

Search

Navigation