Skip to main content
Log in

Synthesis and characterization of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols — a new series of fused indazole derivatives

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A novel class of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols is synthesized and characterized by melting point, elemental analysis, MS, FT-IR, 1H and 13C NMR, D2O exchanged 1H NMR, and two-dimensional HSQC spectra.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. L. Cecchi, F. Melani, G. Filacchioni, and M. Tredici, Farmaco, 39, 945 (1984).

    CAS  Google Scholar 

  2. Jong Hee Ko, Seung Woo Yeon, Jung Su Ryu, Tae-Yong Kim, Eun-Ha Song, Hea-Jung You, Rae-Eun Park, and Chung-Kyu Ryu, Bioorg. Med. Chem. Lett., 16, 6001 (2006).

    Article  CAS  Google Scholar 

  3. A. Gerpe, G. Aguirre, L. Boiani, H. Cerecetto, M. Gonzalez, C. Olea-Azar, C. Rigol, J. D. Maya, A. Morello, O. E. Piro, V. J. Aran, A. Azqueta, A. L. de Cerain, A. Monge, M. A. Rojas, and G. Yaluff, Bioorg. Med. Chem., 14, 3467 (2006).

    Article  CAS  Google Scholar 

  4. X. Li, S. Chu, V. A. Feher, M. Khalili, Z. Nie, S. Margosiak, V. Nikulin, J. Levin, K. G. Sprankle, M. E. Tedder, R. Almassy, K. Appelt, and K. M. Yager, J. Med. Chem., 46, 5663 (2003).

    Article  CAS  Google Scholar 

  5. D. L. Selwood, D. G. Brummell, J. Budworth, G. E. Burtin, R. O. Campbell, S. Chana, I. G. Charles, P. A. Fernandez, R. C. Glen, M. C. Goggin, A. J. Hobbs, M. R. Kling, Q. Liu, D. J. Madge, S. Meillerais, K. L. Powell, K. Reynolds, G. D. Spacey, J. N. Stables, M. A. Tatlock, K. A. Wheelers, G. Wishart, and C. Woo, J. Med. Chem., 44, 78 (2001).

    Article  CAS  Google Scholar 

  6. M. Balasubramanian and A. D'Souza, Tetrahedron, 24, 5399 (1968).

    Article  CAS  Google Scholar 

  7. M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, V. Kanagarajan, R. Govindaraju, and G. Jayasri, J. Enz. Inhib. Med. Chem., 22, 709 (2007).

    Article  CAS  Google Scholar 

  8. M. Gopalakrishnan, P. Sureshkumar, J. Thanusu, C. Prabhu, and V. Kanagarajan, J. Chem. Res., 2, 80 (2007).

    Google Scholar 

  9. M. Gopalakrishnan, P. Sureshkumar, V. Kanagarajan, and J. Thanusu, J. Sulfur Chem., 28, 383 (2007).

    Article  CAS  Google Scholar 

  10. T. Balasankar, M. Gopalakrishnan, and S. Nagarajan, J. Enz. Inhib. Med. Chem., 22, 171 (2007).

    Article  CAS  Google Scholar 

  11. T. Balasankar, M. Gopalakrishnan, and S. Nagarajan, Eur. J. Med. Chem., 40, 728 (2005).

    Article  CAS  Google Scholar 

  12. W. Guthrie, Can. J. Chem., 69, 339 (1991).

    Article  CAS  Google Scholar 

  13. W. Guthrie, J. Am. Chem. Soc., 109, 6609 (1991).

    Google Scholar 

  14. A. T. Nielson and W. Houlihan, J. Org. React., 16, 1 (1968).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. Gopalakrishnan.

Additional information

__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1183–1188, August, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gopalakrishnan, M., Thanusu, J. & Kanagarajan, V. Synthesis and characterization of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols — a new series of fused indazole derivatives. Chem Heterocycl Comp 44, 950–955 (2008). https://doi.org/10.1007/s10593-008-0137-y

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-008-0137-y

Keywords

Navigation