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Polyfunctional nitriles in the synthesis of derivatives of 1,3,4-thiadiazolo-[3,2-a]pyrimidines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A one-pot method has been developed for the synthesis of 2-R-7-methyl-5-oxo-5H-1,3,4-thia-diazolo[3,2-a]pyrimidine by condensation of β-alkylthio(alkoxy)propionitrile, thiosemicarbazide, and ethyl acetoacetate in PPA, and also (7-methyl-5-oxo-5H-1,3,4-thidiazolo[3,2-a]pyrimidin-2-yl)-acetamide from cyanoacetamide, thiosemicarbazide, and ethyl acetoacetate.

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Authors and Affiliations

  1. V. I. Nikitin Institute of Chemistry, Tadzhikistan Academy of Sciences, Dushanbe, 734063, Tadzhikistan

    M. A. Kukaniev, M. D. Osimov, Z. G. Sangov, S. S. Safarov, M. B. Karimov & T. R. Radjabov

Authors
  1. M. A. Kukaniev
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  2. M. D. Osimov
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  3. Z. G. Sangov
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  4. S. S. Safarov
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  5. M. B. Karimov
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  6. T. R. Radjabov
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Correspondence to M. A. Kukaniev.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, 1096–1100, July, 2008.

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Kukaniev, M.A., Osimov, M.D., Sangov, Z.G. et al. Polyfunctional nitriles in the synthesis of derivatives of 1,3,4-thiadiazolo-[3,2-a]pyrimidines. Chem Heterocycl Comp 44, 882–885 (2008). https://doi.org/10.1007/s10593-008-0125-2

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  • DOI: https://doi.org/10.1007/s10593-008-0125-2

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