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Chemistry of Heterocyclic Compounds

, Volume 44, Issue 7, pp 845–851 | Cite as

Condensed isoquinolines 32. Synthesis of 4H-thieno-[3′,2′:5,6]-and-[2′,3′: 5,6]pyrimido-[1,2-b]isoquinolines and 6,12-dihydro-5H-isoquino-[2,3-a]quinazoline-5,12-dione derivatives

  • A. V. Zadorozhny
  • V. A. Kovtunenko
  • A. V. Turov
  • T. T. Kucherenko
Article

Abstract

Treatment of 2-(4-oxo-3,4-dihydrothieno[2,3-d]-and-[3,2-d]pyrimidin-2-ylmethyl)benzoic acids and 2-(4-oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic acid with acetic anhydride gave thieno[3′,2′:5,6]-and-[2′,3′:5,6]pyrimido[1,2-b]isoquinoline-4,11-diones and isoquino[2,3-a]quinazoline-5,12-dione respectively. NMR spectroscopy showed that an intramolecular acylation of the above acids occurs at the atom N-1 of the pyrimidinone part of the bicycle.

Keywords

isoquinoquinazoline-5,12-dione 4-oxopyrimidinones thienopyrimidinones thieno-pyrimidoisoquinoline-4,11-diones quinazolines 

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • A. V. Zadorozhny
    • 1
  • V. A. Kovtunenko
    • 1
  • A. V. Turov
    • 1
  • T. T. Kucherenko
    • 1
  1. 1.Taras Shevchenko National UniversityKievUkraine

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