Abstract
Treatment of 2-(4-oxo-3,4-dihydrothieno[2,3-d]-and-[3,2-d]pyrimidin-2-ylmethyl)benzoic acids and 2-(4-oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic acid with acetic anhydride gave thieno[3′,2′:5,6]-and-[2′,3′:5,6]pyrimido[1,2-b]isoquinoline-4,11-diones and isoquino[2,3-a]quinazoline-5,12-dione respectively. NMR spectroscopy showed that an intramolecular acylation of the above acids occurs at the atom N-1 of the pyrimidinone part of the bicycle.
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L. M. Potikha, V. M. Kisil, A. V. Turov, and V. A. Kovtunenko, Khim. Geterotsikl. Soedin., 1044 (2008). [Chem. Heterocycl. Comp., 44, 838 (2008)].
T. T. Kucherenko, A. V. Zadorozhny, and V. A. Kovtunenko, Khim. Geterotsikl. Soedin., 932 (2008). [Chem. Heterocycl. Comp., 44, 750 (2008)].
V. A. Kovtunenko, T. T. Kucherenko, O. V. Shishkin, and V. M. Kisil, Khim. Geterotsikl. Soedin., 1408 (2002). [Chem. Heterocycl. Comp., 38, 1242 (2002)].
Organikum [Russian translation], Vol. 2, Mir, Moscow (1992), p. 84.
H. Hosni and W. Basyouni, Acta Pol. Pharm., 56, 49 (1999).
H. Hosni and W. Basyouni, J. Chem. Res. Miniprint, 11, 2775 (1999).
HyperChem Professional 5.1, Hypercube©Inc. 2002 (presented by Prof. O. D. Kachovskii, Institute of Organic Chemistry, Ukraine National Academy of Sciences, Kiev).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1053–1061, July, 2008.
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Zadorozhny, A.V., Kovtunenko, V.A., Turov, A.V. et al. Condensed isoquinolines 32. Synthesis of 4H-thieno-[3′,2′:5,6]-and-[2′,3′: 5,6]pyrimido-[1,2-b]isoquinolines and 6,12-dihydro-5H-isoquino-[2,3-a]quinazoline-5,12-dione derivatives. Chem Heterocycl Comp 44, 845–851 (2008). https://doi.org/10.1007/s10593-008-0119-0
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DOI: https://doi.org/10.1007/s10593-008-0119-0