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Investigation of the conformational transformations in some 7α-methyl-6-oxa-14β-analogs of steroidal estrogens by NMR spectroscopy

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The stereochemical structure and conformational transformations of two 6-oxa-14β-estra-1,3,5(10), 8(9)-tetraenes having an α-methyl group at position 7 were investigated. It was found that the substituent at the C-17 atom has an effect on the formation of the conformers in solution. In the analog containing a C-17 keto group in solution there are two conformers, whereas the 17α-acetoxy derivative has only one conformer.

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Authors and Affiliations

  1. Chemical Faculty, St. Petersburg State University, St. Petersburg, 198504, Russia

    S. I. Selivanov, S. N. Morozkina, A. S. Chentsova & A. G. Shavva

Authors
  1. S. I. Selivanov
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  2. S. N. Morozkina
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  3. A. S. Chentsova
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  4. A. G. Shavva
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Corresponding author

Correspondence to S. I. Selivanov.

Additional information

In memory of Prof. A. A. Potekhin.

__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 82–834, June, 2008.

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Selivanov, S.I., Morozkina, S.N., Chentsova, A.S. et al. Investigation of the conformational transformations in some 7α-methyl-6-oxa-14β-analogs of steroidal estrogens by NMR spectroscopy. Chem Heterocycl Comp 44, 654–665 (2008). https://doi.org/10.1007/s10593-008-0091-8

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  • DOI: https://doi.org/10.1007/s10593-008-0091-8

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