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Diastereoselective reductive amination of pyrazolidinyl alkyl ketones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Reductive amination of pyrazolidinyl alkyl ketones with sodium triacetoxyborohydride or sodium tripivaloyloxyborohydride takes place diastereoselectively with the formation of aminoalkylpyrazolidines of trans structure. The volume of the substituent in the borohydrides does not affect the ratio of stereoisomers.

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Authors and Affiliations

  1. Chemical Faculty, M. V. Lomonosov State Moscow University, Moscow, 119899, Russia

    L. A. Sviridova & G. A. Golubeva

  2. A. N. Nesmeyanov Institute of Oganoelement Compounds, Russian Academy of Sciences, Moscow, 119991, Russia

    A. N. Tavtorkin, Yu. V. Nelyubina & K. A. Kochetkov

Authors
  1. L. A. Sviridova
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  2. G. A. Golubeva
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  3. A. N. Tavtorkin
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  4. Yu. V. Nelyubina
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  5. K. A. Kochetkov
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Corresponding author

Correspondence to L. A. Sviridova.

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Dedicated to the memory of A. A. Potekhin, renowned teacher, scientist, and editor of journal “Chemistry of Heterocyclic Compounds”

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 691–698, May, 2008.

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Sviridova, L.A., Golubeva, G.A., Tavtorkin, A.N. et al. Diastereoselective reductive amination of pyrazolidinyl alkyl ketones. Chem Heterocycl Comp 44, 542–548 (2008). https://doi.org/10.1007/s10593-008-0073-x

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  • DOI: https://doi.org/10.1007/s10593-008-0073-x

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