Abstract
We have studied the reaction of 2,5-dimethoxytetrahydrofuran with 4,6-disubstituted 2-amino-1,3,5-triazines with the aim of obtaining novel coupled polyheterocyclic systems with potential bioactivity. Reaction conditions were optimized. A series of novel 4,6-disubstituted 2-(1H-1-pyrrolyl)-sym-triazines was obtained. It was found that the product yields depended on the nature of the substituent in the 4 and 6 positions of the triazine ring and on the reaction conditions.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 440–451, March, 2008.
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Chesnyuk, A.A., Mikhailichenko, S.N., Zaplishnyi, V.N. et al. sym-triazines. 8. Synthesis and some reactions of 4,6-disubstituted 2-(1H-pyrrolyl)-1,3,5-triazines. Chem Heterocycl Comp 44, 339–348 (2008). https://doi.org/10.1007/s10593-008-0050-4
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DOI: https://doi.org/10.1007/s10593-008-0050-4