Chemistry of Heterocyclic Compounds

, Volume 44, Issue 3, pp 301–308 | Cite as

Regioselective synthesis of fluorine-containing indazolones from 2-acylcyclohexane-1,3-diones

  • T. S. Khlebnicova
  • V. G. Isakova
  • F. A. Lakhvich
  • P. V. Kurman


New regioisomeric indazolones containing fluorine atoms in the aromatic ring have been synthesized in high yield by the interaction of 2-acylcyclohexane-1,3-diones, and of their enol methyl ethers, obtained by methylating the initial β,β′-triketones with dimethyl sulfate in the presence of calcined potassium carbonate, with 4-fluorophenylhydrazine hydrochloride and with pentafluorophenylhydrazine. The structures of the synthesized compounds were confirmed by data of IR and 1H, 13C, and 19F NMR spectra.


2-acylcyclohexane-1,3-diones fluorine-containing indazolones regioselective synthesis 


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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • T. S. Khlebnicova
    • 1
  • V. G. Isakova
    • 1
  • F. A. Lakhvich
    • 1
  • P. V. Kurman
    • 2
  1. 1.Institute of Bioorganic ChemistryNational Academy of Sciences of BelarusMinskBelarus
  2. 2.The Republican Scientific and Engineering Center for Remote Sensing of Environment “EKOMIR”National Academy of Sciences of the Republic of BelarusMinskBelarus

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