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4-Hydroxy-2-quinolones 138. Synthesis and study of structure-biological activity relationships in a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid anilides

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Two methods are discussed and the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid anilides has been carried out. The antitubercular activity and the effect on the urinary function of the kidney have been studied for the compounds prepared. A structure-biological activity relationship is discussed.

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Authors and Affiliations

  1. National University of Pharmacy, Kharkiv, 61002, Ukraine

    I. V. Ukrainets, E. V. Mospanova, N. L. Bereznyakova & O. I. Naboka

Authors
  1. I. V. Ukrainets
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  2. E. V. Mospanova
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  3. N. L. Bereznyakova
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  4. O. I. Naboka
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Correspondence to I. V. Ukrainets.

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__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1808–1819, December, 2007.

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Ukrainets, I.V., Mospanova, E.V., Bereznyakova, N.L. et al. 4-Hydroxy-2-quinolones 138. Synthesis and study of structure-biological activity relationships in a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid anilides. Chem Heterocycl Comp 43, 1532–1539 (2007). https://doi.org/10.1007/s10593-007-0237-0

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  • DOI: https://doi.org/10.1007/s10593-007-0237-0

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