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Synthesis and reactivity of 3-amino-9-methoxymethyl-7-methyl-3,4-dihydropyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-ones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of acyl derivatives of ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate with hydrazine hydrate gives a series of tricyclic 3-amino-3,4-dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-ones containing aliphatic, aromatic, or heteroaromatic fragments at C(2). The reactions of 3-aminopyridothieno[3,2-d]pyrimidin-4-ones with aldehydes, formamide, 2,5-dimethoxytetrahydrofuran, acetic anhydride, and Raney nickel were studied.

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Authors and Affiliations

  1. Kuban State Technological University, Krasnodar, 350072, Russia

    E. S. Kostenko & M. M. Lipunov

  2. Kuban State Agrarian University, Krasnodar, 350044

    E. A. Kaigorodova

  3. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119992, Russia

    L. D. Konyushkin

Authors
  1. E. S. Kostenko
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  2. M. M. Lipunov
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  3. E. A. Kaigorodova
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  4. L. D. Konyushkin
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Correspondence to E. S. Kostenko.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1720–1732, November, 2007.

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Kostenko, E.S., Lipunov, M.M., Kaigorodova, E.A. et al. Synthesis and reactivity of 3-amino-9-methoxymethyl-7-methyl-3,4-dihydropyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-ones. Chem Heterocycl Comp 43, 1466–1476 (2007). https://doi.org/10.1007/s10593-007-0226-3

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  • DOI: https://doi.org/10.1007/s10593-007-0226-3

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