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Chemistry of Heterocyclic Compounds

, Volume 43, Issue 11, pp 1434–1439 | Cite as

4-Hydroxy-2-quinolones 132. Synthesis, chemical, and biological properties of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides

  • I. V. UkrainetsEmail author
  • L. V. Sidorenko
  • O. S. Golovchenko
Article

Abstract

1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical N,N′-di(4-hydroxy-2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds has been carried out.

Keywords

hydrazides 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids amidation reduction antitubercular activity 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • I. V. Ukrainets
    • 1
    Email author
  • L. V. Sidorenko
    • 1
  • O. S. Golovchenko
    • 1
  1. 1.National University of PharmacyKharkivUkraine

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