Chemistry of Heterocyclic Compounds

, Volume 43, Issue 11, pp 1411–1419 | Cite as

Synthesis and reactions of 1-R-3-benzoyl-5-ethoxycarbonyl-6-oxo-1,2,3,6-tetrahydropyridine-2-thiones

  • V. N. BritsunEmail author
  • A. N. Esipenko
  • A. N. Chernega
  • E. B. Rusanov
  • M. O. Lozinskii


Cycloacylation of N-R-3-oxo-3-phenylpropanethioamides by diethyl ethoxymethylenemalonate occurs selectively to form 1-R-3-benzoyl-5-ethoxycarbonyl-6-oxo-1,2,3,6-tetrahydropyridine-2-thiones which are convenient starting materials for the synthesis of bi-and tricyclic hetero systems including the previously unknown 9-R-7-ethoxycarbonyl-5-phenyl-8,9-dihydropyrido[2,3-d][1,2,4]triazolo[1,5-a]-pyrimidin-8-ones.


1-R-3-benzoyl-5-ethoxycarbonyl-6-oxo-1,2,3,6-tetrahydropyridine-2-thiones diethyl ethoxymethylenemalonate 6-ethoxycarbonyl-2-imino-8-methyl-4-phenyl-1,2,7,8-tetrahydropyrido[2,3-d]-pyrimidin-7-one 5-ethoxycarbonyl-7-methy-3-phenyl-6,7-dihydroisoxazolo[3,4-b]pyridine-6-one N-R-3-oxo-3-phenylpropanethioamides 9-R-7-ethoxycarbonyl-5-phenyl-8,9-dihydropyrido[2,3-d][1,2,4]triazolo-[1,5-a]pyrimidin-8-ones X-ray structural analysis cycloacylation 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • V. N. Britsun
    • 1
    Email author
  • A. N. Esipenko
    • 1
  • A. N. Chernega
    • 1
  • E. B. Rusanov
    • 1
  • M. O. Lozinskii
    • 1
  1. 1.Organic Chemistry InstituteNational Academy of Sciences of UkraineKiev

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