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Chemistry of Heterocyclic Compounds

, Volume 43, Issue 11, pp 1406–1410 | Cite as

α-Ureidoalkylation of 1,3-bis(hydroxymethyl)-imidazolidin-2-one

  • G. A. GazievaEmail author
  • P. V. Lozhkin
  • A. N. Kravchenko
Article

Abstract

The α-ureidoalkylation of imidazolidine-2,4-dione, urea, carboxylic acid amides, and sulfonamides has been studied using 1,3-bis(hydroxymethyl)-imidazolidin-2-one as ureidoalkylating agent. Methods have been developed for the synthesis of 1,3-bis(2,4-dioxoimidazolidin-1-ylmethyl)-, 1,3-bis(acetylaminomethyl)-, 1,3-bis(benzoylaminomethyl)-, 1,3-bis(phenylsulfonylaminomethyl)-, and 1,3-bis(p-toluenesulfonylaminomethyl)imidazolidin-2-ones.

Keywords

1,3-bis(R-aminomethyl)imidazolidin-2-ones 1,3-bis(hydroxymethyl)imidazolidin-2-one 1,3-bis(2,4-dioxoimidazolidin-1-yl)methylimidazolidin-2-one α-ureidoalkylation 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • G. A. Gazieva
    • 1
    Email author
  • P. V. Lozhkin
    • 1
  • A. N. Kravchenko
    • 1
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscow

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