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Chemistry of Heterocyclic Compounds

, Volume 43, Issue 11, pp 1390–1396 | Cite as

Synthesis of 2-(3-furyl)-1H-benzimidazoles from 2-phenacyl-1H-benzimidazoles

  • I. B. DzvinchukEmail author
  • M. O. Lozinskii
Article

Abstract

C-Alkylation at the active methylene group of 2-phenacyl-1H-benzimidazoles with phenacyl bromides proceeds highly selectively with the formation of the corresponding 1,4-diketones, which on heating with hydrochloric acid are cyclized with the formation of the previously unknown 2-(2,5-diaryl-3-furyl)-1H-benzimidazoles.

Keywords

benzimidazoles phenacyl bromides furans C-alkylation selectivity cyclocondensation 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Institute of Organic ChemistryNational Academy of Sciences of UkraineKiev

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