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Synthesis of 2-(3-furyl)-1H-benzimidazoles from 2-phenacyl-1H-benzimidazoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

C-Alkylation at the active methylene group of 2-phenacyl-1H-benzimidazoles with phenacyl bromides proceeds highly selectively with the formation of the corresponding 1,4-diketones, which on heating with hydrochloric acid are cyclized with the formation of the previously unknown 2-(2,5-diaryl-3-furyl)-1H-benzimidazoles.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev, 02094

    I. B. Dzvinchuk & M. O. Lozinskii

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  1. I. B. Dzvinchuk
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  2. M. O. Lozinskii
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Correspondence to I. B. Dzvinchuk.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1637–1645, November, 2007.

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Dzvinchuk, I.B., Lozinskii, M.O. Synthesis of 2-(3-furyl)-1H-benzimidazoles from 2-phenacyl-1H-benzimidazoles. Chem Heterocycl Comp 43, 1390–1396 (2007). https://doi.org/10.1007/s10593-007-0215-6

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  • DOI: https://doi.org/10.1007/s10593-007-0215-6

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