Chemistry of Heterocyclic Compounds

, Volume 43, Issue 7, pp 871–878 | Cite as

4-Hydroxy-2-quinolones 123. Amidation of 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]-quinoline-4-carboxylic acid

  • I. V. Ukrainets
  • N. L. Bereznyakova
  • A. V. Turov
  • S. V. Shishkina


The reaction of 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline-4-carboxylic acid with thionyl chloride is accompanied by a transformation of the oxazoloquinolone ring to give 4-chloro-1-(2,3-dichloropropyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid chloride.


oxazolo[3,2-a]quinoline 4-chloro-2-quinolinone amidation ring closing X-ray analysis 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • N. L. Bereznyakova
    • 1
  • A. V. Turov
    • 2
  • S. V. Shishkina
    • 3
  1. 1.National University of PharmacyKharkivUkraine
  2. 2.Taras Shevchenko National UniversityKievUkraine
  3. 3.STC Institute for Single CrystalsNational Academy of SciencesKharkivUkraine

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