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Chemistry of Heterocyclic Compounds

, Volume 43, Issue 7, pp 856–862 | Cite as

4-Hydroxy-2-quinolones 121. Synthesis and biological properties of 1-hydroxy-3-oxo-5,6-dihydro-3h-pyrrolo[3,2,1-ij]quino-line-2-carboxylic acid alkylamides

  • I. V. Ukrainets
  • N. L. Bereznyakova
  • E. V. Mospanova
Article

Abstract

A simple method is proposed for preparing 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]-quinoline-2-carboxylic acid alkylamides. For the case of the secondary butylamide features of the steric structure of the synthesized compounds is discussed. The results of a study of their anti-inflammatory and diuretic activities are presented.

Keywords

alkylamides 4-hydroxy-2-oxoquinoline-3-carboxylic acids diuretic activity anti-inflammatory activity X-ray structural analysis 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • N. L. Bereznyakova
    • 1
  • E. V. Mospanova
    • 1
  1. 1.National University of PharmacyKharkivUkraine

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