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Chemistry of Heterocyclic Compounds

, Volume 43, Issue 6, pp 729–739 | Cite as

4-Hydroxy-2-quinolones 120. Synthesis and structure of ethyl 2-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-3-carboxylate

  • I. V. Ukrainets
  • N. L. Bereznyakova
  • G. P. Petyunin
  • I. A. Tugaibei
  • V. B. Rybakov
  • V. V. Chernyshev
  • A. V. Turov
Article

Abstract

An improved method for the preparation and purification of ethyl 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylates is proposed. According to 1H and 13C NMR spectroscopic data the synthesized compounds exist in DMSO solution in the 2-hydroxy-4-oxo form while in the crystal (at least for the case of the unsubstituted derivative) X-ray analysis shows that it occurs in the bipolar 2,4-dioxo form.

Keywords

2-aminopyridines heterocyclic tricarbonylmethane derivatives 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids esters X-ray analysis 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • I. V. Ukrainets
    • 1
  • N. L. Bereznyakova
    • 1
  • G. P. Petyunin
    • 1
  • I. A. Tugaibei
    • 1
  • V. B. Rybakov
    • 2
  • V. V. Chernyshev
    • 2
  • A. V. Turov
    • 3
  1. 1.National University of PharmacyKharkivUkraine
  2. 2.M. V. Lomonosov Moscow State UniversityMoscowRussia
  3. 3.Taras Shevchenko National UniversityKievUkraine

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