Abstract
The reactions of N-substituted maleimides with aminouracils and derivatives of aniline were carried out. The structures of the synthesized compounds were verified by the data from elemental analysis and by the UV, IR, and 1H NMR spectra. The physicochemical characteristics, toxicity, and biological activity of the new compounds were studied.
Similar content being viewed by others
References
M. Abou-Charbia, U. R. Patel, and M. B. Webb, J. Med. Chem., 31, 1382 (1988).
D. A. Cooncy, H. A. Milman, and R. G. Cable, Biochem. Pharmacol., 27(2), 151 (1978).
V. Balasubramaniyan, P. Balasubramaniyan, and A. S. Shaikh, Tetrahedron, 42, 2731 (1986).
E. V. Velchinskaya, I. I. Kuzmenko, and L. S. Kulik, Khim.-Farm. Zh., No. 3, 40 (1999).
M. Farcaslu and R. Istratolu, Rev. Roum. Chim., 15, No. 12, 253 (1970).
British Pharmacopoeia, CD-ROM, 3 (1999).
V. B. Prozorovskii, V. P. Prozorovskaya, and V. M. Demchenko, Farmakologiya i Toksikologiya, 497 (1978).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 828–833, June, 2007.
Rights and permissions
About this article
Cite this article
Velchinskaya, E., Petsushak, B. & Rogal, A. Investigation of the physicochemical characteristics and biological activity of new derivatives of N-substituted maleimides. Chem Heterocycl Compd 43, 695–700 (2007). https://doi.org/10.1007/s10593-007-0113-y
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/s10593-007-0113-y