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4-Hydroxy-2-quinolones. 118. Synthesis, structure, and chemical properties of 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo-[3,2-a]quinoline-4-carboxylic acid and its ethyl ester

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Abstract

Bromination of N-allyl-substituted 4-hydroxy-2-quinolinones with molecular bromine in acetic acid or carbon tetrachloride occurs with closing of a five membered oxazole ring to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline.

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Authors and Affiliations

  1. National University of Pharmacy, Kharkiv, 61002, Ukraine

    I. V. Ukrainets, L. V. Sidorenko & O. V. Gorokhova

  2. NTC Institute for Single Crystals, National Academy of Sciences Ukraine, Kharkiv, 61001

    S. V. Shishkina

  3. Taras Shevchenko Kiev National University, Kiev, 01033, Ukraine

    A. V. Turov

Authors
  1. I. V. Ukrainets
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  2. L. V. Sidorenko
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  3. O. V. Gorokhova
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  4. S. V. Shishkina
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  5. A. V. Turov
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 736–749, May, 2007.

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Ukrainets, I.V., Sidorenko, L.V., Gorokhova, O.V. et al. 4-Hydroxy-2-quinolones. 118. Synthesis, structure, and chemical properties of 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo-[3,2-a]quinoline-4-carboxylic acid and its ethyl ester. Chem Heterocycl Compd 43, 617–628 (2007). https://doi.org/10.1007/s10593-007-0096-8

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  • DOI: https://doi.org/10.1007/s10593-007-0096-8

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