Chemistry of Heterocyclic Compounds

, Volume 43, Issue 3, pp 370–376 | Cite as

Synthesis of new 2-amino-5-hydroxymethyl-2-thiazolines

  • T. P. Trofimova
  • A. N. Pushin
  • A. N. Proshin
  • A. I. Stash
  • A. A. Mandrugin
  • V. M. Fedoseev
  • S. Ya. Proskuryakov


A simple and convenient method is proposed for the synthesis of 2-amino-5-hydroxymethylthiazolines with various substituents in the amino group, which is based on hydrolysis of the corresponding 5-halomethyl derivatives of thiazoline in the presence of divalent lead oxide.


2-amino-5-hydroxymethyl-2-thiazoline nitric oxide hydrolysis X-ray structural analysis NMR 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • T. P. Trofimova
    • 1
  • A. N. Pushin
    • 2
  • A. N. Proshin
    • 2
  • A. I. Stash
    • 3
  • A. A. Mandrugin
    • 1
  • V. M. Fedoseev
    • 1
  • S. Ya. Proskuryakov
    • 4
  1. 1.Chemical FacultyM. V. Lomonosov Moscow State UniversityMoscowRussia
  2. 2.Institute of Physiologically Active CompoundsRussian Academy of Sciences, ChernogolovkaMoscow Region
  3. 3.Karpov Institute of Physical ChemistryMoscowRussia
  4. 4.Medical Radiological Research CenterRussian Academy of Medical Sciences, ObninskMoscow Region

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