Skip to main content
SpringerLink
Log in

4-Hydroxy-2-quinolones 113. Synthesis and antitubercular activity of N-R-amides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A preparative method has been developed and the synthesis has been effected of anilides and heterylamides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid. A comparative analysis has been carried out of the structure and antitubercular properties of the synthesized compounds and their analogs unsubstituted in the quinoline nucleus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. V. Ukrainets, L. V. Sidorenko, O. V. Gorokhova, and S. V. Slobodzyan, Khim. Geterotsikl. Soedin., 75 (2007).

  2. G. I. Zhungietu and V. G. Granik, Main Principles of Drug Design, Izdatel.-poligraph. Complex, State Univ. Moldova, Kishinev (2000).

    Google Scholar 

  3. I. V. Ukrainets, E. V. Kolesnik, L. V. Sidorenko, O. V. Gorokhova, and A. V. Turov, Khim. Geterotsikl. Soedin., 874 (2006). [Chem. Heterocycl. Comp., 42, 765 (2006)].

    Google Scholar 

  4. H. Gunther, NMR Spectroscopy: Basic Principles, Concepts, and Applications in Chemistry. John Wiley & Sons, Chichester (1995).

    Google Scholar 

  5. H.-B. Burgi and J. D. Dunitz, Struct. Correl., Vol. 2, VCH, Weinheim (1994), 741 pp.

    Google Scholar 

  6. Yu. V. Zefirov and P. M. Zorkii, Usp. Khim., 58, 713 (1989).

    CAS  Google Scholar 

  7. G. M. Sheldrick, SHELX97. PC Version. A System of Computer Programs for Crystal Structure Solution and Refinement, Rev. 2 (1998).

Download references

Author information

Authors and Affiliations

  1. National Pharmaceutical University, Kharkiv, 61002, Ukraine

    I. V. Ukrainets, E. V. Kolesnik, L. V. Sidorenko & O. V. Gorokhova

  2. Kiev Taras Shevchenko National University, Kiev, 01033, Ukraine

    A. V. Turov

Authors
  1. I. V. Ukrainets
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Kolesnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. V. Sidorenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. V. Gorokhova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. V. Turov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 405–414, March, 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ukrainets, I.V., Kolesnik, E.V., Sidorenko, L.V. et al. 4-Hydroxy-2-quinolones 113. Synthesis and antitubercular activity of N-R-amides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid. Chem Heterocycl Compd 43, 326–333 (2007). https://doi.org/10.1007/s10593-007-0049-2

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-007-0049-2

Keywords

Search

Navigation