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Synthesis and anticancer properties of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The tert-butyl esters of 3-azidomethyl-, 3-isocyanatomethyl-, 3-chloromethyl-, and 3-p-nitrophenylvinyl-7α-chloro-1,1-dioxoceph-3-em-4-carboxylic acid, and also esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid, and of 7α-chloro-3-methyl-2-dimethylaminomethylene-1,1-dioxoceph-3-em-4-carboxylic acid have been synthesized. Results of cytotoxic screening of these compounds in relation to cancer and normal cells in vitro are correlated and analyzed.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, LV-1006

    M. Vorona, G. Veinberg, I. Shestakova, I. Kanepe, I. Potorochina, K. Dikovskaya, R. Bokaldere, M. Petrova, E. Liepinsh & E. Lukevics

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  1. M. Vorona
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  2. G. Veinberg
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  3. I. Shestakova
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  4. I. Kanepe
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  5. I. Potorochina
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  6. K. Dikovskaya
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  7. R. Bokaldere
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  8. M. Petrova
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  9. E. Liepinsh
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  10. E. Lukevics
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__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 259–273, February, 2007.

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Vorona, M., Veinberg, G., Shestakova, I. et al. Synthesis and anticancer properties of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters. Chem Heterocycl Compd 43, 207–219 (2007). https://doi.org/10.1007/s10593-007-0033-x

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  • DOI: https://doi.org/10.1007/s10593-007-0033-x

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