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Chemistry of Heterocyclic Compounds

, Volume 43, Issue 2, pp 207–219 | Cite as

Synthesis and anticancer properties of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid esters

  • M. Vorona
  • G. Veinberg
  • I. Shestakova
  • I. Kanepe
  • I. Potorochina
  • K. Dikovskaya
  • R. Bokaldere
  • M. Petrova
  • E. Liepinsh
  • E. Lukevics
Article

Abstract

The tert-butyl esters of 3-azidomethyl-, 3-isocyanatomethyl-, 3-chloromethyl-, and 3-p-nitrophenylvinyl-7α-chloro-1,1-dioxoceph-3-em-4-carboxylic acid, and also esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid, and of 7α-chloro-3-methyl-2-dimethylaminomethylene-1,1-dioxoceph-3-em-4-carboxylic acid have been synthesized. Results of cytotoxic screening of these compounds in relation to cancer and normal cells in vitro are correlated and analyzed.

Keywords

esters of 7α-chloro-3-methyl-2-dimethylaminomethylene-1,1-dioxoceph-3-em-4-carboxylic acid esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid cytotoxic activity 

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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • M. Vorona
    • 1
  • G. Veinberg
    • 1
  • I. Shestakova
    • 1
  • I. Kanepe
    • 1
  • I. Potorochina
    • 1
  • K. Dikovskaya
    • 1
  • R. Bokaldere
    • 1
  • M. Petrova
    • 1
  • E. Liepinsh
    • 1
  • E. Lukevics
    • 1
  1. 1.Latvian Institute of Organic SynthesisRiga

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