Abstract
1-[5-(3-Arylisoxazolin-2-yl)methyl]-3,7-dimethylxanthines have been synthesized by the [2+3] cycloaddition of arylnitrile oxides to allyltheobromine. 7-{5-[3-(2,4-Dichlorophenyl)isoxazolin-2-yl]methyl}-1,3-dimethylxanthine was obtained by the addition of 2,4-dichlorobenzonitrile oxide to allyltheobromine. The addition of arylnitrile oxides to structural isomers of methylxanthines proceeds regioselectively with the formation of 3,5-disubstituted isoxazolines.
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O. S. Usmani, M. G. Belvisi, H. J. Patel, N. Grispino, M. A. Birrell, M. Korbonits, D. Korbonits, and P. J. Barnes, FASEB J., 19, 231 (2005).
A. P. Kozikowski and P. D. Stein, J. Am. Chem. Soc., 104, 4023 (1982).
D. P. Curran, J. Am. Chem. Soc., 105, 5826 (1983).
B. H. Kim, Y. J. Chung, and E. J. Ryu, Tetrahedron Lett., 34, 8465 (1993).
S. H. Andersen, K. K. Sharma, and K. B. G. Torssell, Tetrahedron, 39, 2241 (1983).
P. G. Baraldi, A. Barco, S. Benetti, S. Manfredini, and D. Simoni, Synthesis, 276 (1987).
J. W. Bode and E. M. Carreira, Org. Lett., 3, 1587 (2001).
A. P. Kozikowski and Y. Y. Chen, J. Org. Chem., 46, 5248 (1981).
J. Müller and V. Jäger, Tetrahedron Lett., 23, 4777 (1982).
V. Jäger and H. Grund, Angew. Chem., Int. Ed. Engl., 15, 50 (1976).
S. Y. Lee, B. S. Lee, C. W. Lee, and D. Y. Oh, J. Org. Chem., 65, 256 (2000).
G. W. Moersch, E. L. Wittle, and W. A. Neuklis, J. Org. Chem., 32, 1387 (1967).
A. Yashiro, Y. Nishida, K. Kobayashi, and M. Ohno, Synlett, 361 (2000).
M. J. Tronchet, S. Jaccard-Thorndahl, L. Faivre, and L. Massard, Helv. Chim. Acta, 56, 1303 (1973).
A. A. Hagendern III, B. J. Miller, and J. O. Nagy, Tetrahedron Lett., 21, 229 (1980).
P. G. Baraldi, A. Barco, S. Benetti, G. B. Polline, and D. Simoni, Synthesis, 857 (1987).
V. Jäger and D. Schröter, Synthesis, 556 (1990).
M. De Amici, P. Hagri, C. De Micheli, F. Cateni, R. Bovara, G. Carrea, and G. Casalone, J. Org. Chem., 57, 2825 (1992).
J. W. Paterson, P. S. Cheung, and M. J. Ernest, J. Med. Chem., 35, 507 (1992).
F. Lepage, F. Tonbret, G. Curier, A. Marivain, and J. M. Gillardin, Eur. J. Med. Chem., 27, 581 (1992).
Y. Xiang, J. Chen, R. F. Shinazi, and K. Zhao, Bioorg. Med. Chem., 6, 1051 (1996).
H. Gi, Y. Xiang, J. Chen, R. F. Shinazi, and K. Zhao, J. Org. Chem., 62, 88 (1997).
A. Quilico, in A. Weissburger (editor), Chemistry of Heterocyclic Compounds, Vol. 17, Wiley, New York, London (1962), p. 95.
V. Dirnens, S. Belyakov, and E. Lukevics, Khim. Geterotsikl. Soedin., 450 (2005). [Chem. Heterocycl. Comp., 41, 393 (2005)].
V. Dirnens, O. Slyadevskaya, and E. Lukevics, Khim. Geterotsikl. Soedin., 499 (2002). [Chem. Heterocycl. Comp., 38, 434 (2002)].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii. No. 2, pp. 245–248, February, 2007.
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Dirnens, V., Skrastina, I., Popelis, J. et al. Synthesis of isoxazolinylxanthines. Chem Heterocycl Compd 43, 193–196 (2007). https://doi.org/10.1007/s10593-007-0031-z
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DOI: https://doi.org/10.1007/s10593-007-0031-z