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Microwave-promoted automated synthesis of a coumarin library

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible.

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Authors and Affiliations

  1. Latvian Institute of Organic Synthesis, Riga, Latvia

    M. Katkevičs, A. Kontijevskis, I. Mutule & E. Sūna

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  1. M. Katkevičs
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  2. A. Kontijevskis
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  3. I. Mutule
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  4. E. Sūna
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__________

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 200–208, February, 2007.

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Katkevičs, M., Kontijevskis, A., Mutule, I. et al. Microwave-promoted automated synthesis of a coumarin library. Chem Heterocycl Compd 43, 151–159 (2007). https://doi.org/10.1007/s10593-007-0025-x

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  • DOI: https://doi.org/10.1007/s10593-007-0025-x

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