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1,2,4-Triazoles: Synthetic approaches and pharmacological importance. (Review)

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The synthetic routes of 1,2,4-triazole compounds as well as their pharmacological properties have been described. The review focuses intensively on two methods: cycloaddition reaction in the syntheses of various 1,5-dialky-1H-1,2,4-triazole derivatives from the reactive cumulenes with the nitrile precursors as well as the microwave irradiation method.

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Authors and Affiliations

  1. College of Veterinary Medicine, University of Basrah, Basrah, Iraq

    I. A. Al-Masoudi

  2. Department of Chemistry, College of Science, University of Al al-Bayt, Jordan

    Y. A. Al-Soud

  3. Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq

    N. J. Al-Salihi

  4. Formerly Fachbereich Chemie, Universität Konstanz, Postfach 5560, D-78464, Konstanz, Germany

    N. A. Al-Masoudi

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  1. I. A. Al-Masoudi
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  2. Y. A. Al-Soud
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  3. N. J. Al-Salihi
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  4. N. A. Al-Masoudi
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Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1605–1634, November, 2006.

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Al-Masoudi, I.A., Al-Soud, Y.A., Al-Salihi, N.J. et al. 1,2,4-Triazoles: Synthetic approaches and pharmacological importance. (Review). Chem Heterocycl Compd 42, 1377–1403 (2006). https://doi.org/10.1007/s10593-006-0255-3

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